Bioimpedance for Glucose Monitoring: Electrode Configuration and Metabolic Variability in Experimental Studies

Authors

  • Sebastián Yepes-Largo Centro de Investigación y Desarrollo Tecnológico en Electroquímica
  • Aarón Rodríguez-Lopez Universidad Politécnica de Santa Rosa Jáuregui
  • Rene Antaño-López Centro de Investigación y Desarrollo Tecnológico en Electroquímica

DOI:

https://doi.org/10.13053/cys-29-2-5676

Keywords:

Electrode geometry, skin impedance sensor, non-invasive method, skin resistance, resistivity-glucose correlation

Abstract

The search for non-invasive methods to estimate blood glucose levels has driven research into bioimpedance based on Electrochemical Impedance Spectroscopy (EIS) [1,2]. Various studies have demonstrated correlations between glucose levels and the electrical properties of the skin measured through impedance [3]. To enhance accuracy, optimizing factors such as electrode geometry is essential. This work investigated the configuration of contiguous parallel plate electrodes through simulations and experimental measurements in skin analog materials (SAM) and human skin. Measurements on three healthy volunteers, combining impedance and glucometry, examined glucose absorption and its effects on skin resistance. The results revealed impedance changes reflecting metabolic alterations induced by glucose, consistent with previous studies. Continuous measurements over 2.5 hours showed a probable correlation between impedance and blood glucose levels, albeit with a delay due to tissue differences, highlighting the complexity of the skin's response to glucose.

Downloads

Published

2025-06-18

Issue

Vol. 29 No. 2 (2025): 29(2) 2025

Section

Articles of the Thematic Section

License 

Hereby I transfer exclusively to the Journal "Computación y 
Sistemas", published by the Computing Research Center (CIC-IPN),
the Copyright of the aforementioned paper. I also accept that these 
rights will not be transferred to any other publication, in any other 
format, language or other existing means of developing.
I certify that the paper has not been previously disclosed or simultaneo
usly submitted to any other publication, and that it does not contain 
material whose publication would violate the Copyright or other 
proprietary rights of any person, company or institution. I certify that 
I have the permission from the institution or company where I work or 
study to publish this work.
The representative author accepts the responsibility for the publication
of this paper on behalf of each and every one of the authors. 
This transfer is subject to the following conditions:
  • The authors retain all ownership rights (such as patent rights) of this work, except for the publishing rights transferred to the CIC, through this document.
  • Authors retain the right to publish the work in whole or in part in any book they are the authors or publishers. They can also make use of this work in conferences, courses, personal web pages, and so on.
  • Authors may include working as part of his thesis, for non-profit distribution only.