DNA Characterization through Nanotechnology-Assisted Bioimpedance and Feature Extraction for Artificial Intelligence

Authors

  • Mara Y. Alcantar-Jacobo Instituto Tecnológico Superior de Ciudad Hidalgo
  • Jorge A. Ruiz Romero Instituto Politécnico Nacional
  • Jaime E. López-Madrigal Instituto Politécnico Nacional
  • Leticia Arias-González Instituto Politécnico Nacional
  • Virginia Sánchez-Monroy Instituto Politécnico Nacional
  • César A. González-Díaz Instituto Politécnico Nacional

DOI:

https://doi.org/10.13053/cys-29-2-5699

Keywords:

Bioimpedance, DNA, Magnetic nanoparticles

Abstract

Detecting Deoxyribonucleic Acids (DNA) through their electrical properties is a technique that has not been fully explored. Developing biosensors for detecting label-free DNA without functionalizing transducer surfaces continues to be a relevant technological challenge. Our research group has reported multi-frequency bioimpedance measurements as a potential technique for estimating concentrations of total DNA free of labeling and functionalization. Post-processing techniques, feature extraction, and Artificial Intelligence (AI) algorithms are required for automatic classification and bioimpedance parameters identification that might be used to detect DNA and its concentration. This article explores multi-frequency bioimpedance measurements assisted with magnetic nanoparticles and post-processing AI feature extraction to correlate characteristical bioimpedance parameters with DNA concentrations and purity. Post-processing estimation of the area under the Cole plot seems a relevant feature to correlate with DNA concentration and purity. The results indicate relevant evidence proposing DNA characterization through nanotechnology-assisted bioimpedance and AI.

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Published

2025-06-18

Issue

Vol. 29 No. 2 (2025): 29(2) 2025

Section

Articles of the Thematic Section

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